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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $53 | In Stock | |
10 mg | $89 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $285 | In Stock | |
100 mg | $453 | In Stock | |
1 mL x 10 mM (in DMSO) | $59 | In Stock |
Description | Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research. |
In vitro | Xanomeline stimulates phosphoinositide (PI) hydrolysis in A9 L m1 cells and inhibits [3H]-PZ and [3H]-OXO-M binding to rat brain, with Kis of 7 and 3 nM, respectively[1]. |
In vivo | Xanomeline robustly stimulates in vivo PI hydrolysis, an effect blocked by muscarinic antagonists, indicating mediation by muscarinic receptors. In mice, the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation in the hippocampus is 54 μmole/kg, while in rats, it is 8.1 μmole/kg in the hippocampus[1]. |
Alias | LY246708 oxalate |
Molecular Weight | 371.45 |
Formula | C16H25N3O5S |
Cas No. | 141064-23-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (121.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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